Ecological Niche Models (ENMs) use environmental-climatic factors such as temperature, precipitation, elevation and derived-normalized difference vegetation index to predict climate change effects on disease vectors distribution. There is inadequate information on linkages of current environmental conditions with dengue epidemics and the role of future climatic conditions in determination of potential epidemic risk areas. Hence, we use ENMs such as Maximum Entropy Species Distribution Modelling (MaxEnt) for Ae. aegyptidistribution to explore the geographic distribution of Ae. aegypti in relation to dengue fever epidemics. We also aim to identify bioclimatic conditions correlated with dengue fever epidemics in Tanzania.