Smoking, alcohol and substance abuse defines one of the major harmful causes for unhealthy pregnancy. This research needs to explore the knowledge of women on substance abuse during pregnancy; if at all there is any issue evident of substance abuse among women who live in Mbeya City, then to find out if there are any health related issues among women consumers and their children thereby exploring the measures and strategies that have been taken to combat the situation. Thus, the research aims at collecting data from all women of reproductive age to assess their understanding on the problem of substance abuse at the same time educating them on the importance of abstinence from substance abuse during pregnancy and breast feeding. To do this approximate sample of 300 women of reproductive age will be interviewed. After the collection of data, statistical analysis of the collected data will be performed. And these will show for certain the knowhow of women on substance abuse during antenatal period. Ethical issues are highly considered. This research is aimed to be complete before August 2019; thus, time frame for data collection and compilation will only take four weeks beginning with the first week of 16th June- 10th August!